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・ Broad-bladed tree sponge
・ Broad-eared bat
・ Broad-eared horseshoe bat
・ Broad-faced potoroo
・ Broad-footed climbing mouse
・ Broad-footed mole
・ Broad-headed pipistrelle
・ Broad-headed snake
・ Broad-headed spiny rat
・ Broad-Kenan Streets Historic District
・ Broad-leaved pondweed
・ Broad-leaved tree
・ Broad-palmed frog
・ Broad-snouted caiman
・ Broad-spectrum antibiotic
Broad-Spectrum Chemokine Inhibitor
・ Broad-striped caecilian
・ Broad-striped dasyure
・ Broad-striped Malagasy mongoose
・ Broad-striped tube-nosed fruit bat
・ Broad-tailed gecko
・ Broad-tailed grassbird
・ Broad-tailed hummingbird
・ Broad-tailed paradise whydah
・ Broad-tailed parrot
・ Broad-tipped hermit
・ Broad-toothed field mouse
・ Broad-toothed mouse
・ Broad-toothed tailless bat
・ Broad-winged hawk


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Broad-Spectrum Chemokine Inhibitor : ウィキペディア英語版
Broad-Spectrum Chemokine Inhibitor
A Broad-Spectrum Chemokine Inhibitor or BSCI (also termed Chemotide or Somatotaxin ) is a type of experimental anti-inflammatory drug that inhibits the action of the pro-inflammatory proteins chemokines.
==Early peptides==
The observation that the chemokine CCL2 is potentially responsible for the recruitment of macrophages to atherosclerotic lesions initiated a campaign of research into the a class of molecules that would inhibit the trafficking of leukocytes and act as a new generation of anti-inflammatory agents. ‘Peptide 3’, a dodecapeptide section of CCL2, designed as an allosteric inhibitor of MCP-1 induced leukocyte chemotaxis, was quickly shown by leukocyte migration assay to be a functional inhibitor of many chemokines in vitro with similar potency. The potency of this peptide could be increased by cyclisation and the use of the reverse sequence of D-amino acids. This peptide is called NR58-3.14.3.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Broad-Spectrum Chemokine Inhibitor」の詳細全文を読む



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